HMOX1 and infection: The Nrf2 pathway and HMOX1 have been reported to play a role in "tissue tolerance"—the ability of resist pathogen, inflammation, or oxidative stress-mediated damage during infection or inflammation [66,67] and we have found that HMOX2, a homologous Nrf2-induced gene involved in the antioxidant response, is down regulated in CCC myocardium.