STAG2 and Increased total leukocyte count: In addition, we observed normalization of leukocytosis, monocytosis, and thrombocytopenia in Tet2/Stag2-mutant mice treated with talazoparib (Figure 4C), which was associated with increased numbers of megakaryocytes on blinded review (Figure 4D and Supplemental Figure 4B, P = 0.007).