SLU7 and myelodysplastic syndrome: Myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) are clonal diseases of mutated hematopoietic stem and progenitor cells (HSPCs) characterized by abnormal differentiation and proliferation caused by somatic mutations in genes encoding transcription factors, epigenetic regulators, chromatin modifiers, and splicing factors (4, 5).