Increased expression of inhibitory receptors, including iNKRs, concurrent with a reduction in activation markers like CD28 and HELIOS, as well as loss of proliferative capacity, could be indicative of the expansion or maintenance of a dysfunctional, exhausted-like CD57+CD8+ T cell subset in subjects with better outcomes in T1D. Here, IKZF2 is linked to type 1 diabetes mellitus.