First, we evaluated the CD8+ TEM cell populations expressing cytotoxic and exhaustion-associated markers by flow cytometry analysis (Supplemental Figure 2), given that the gene signature identified by WGCNA included many IR genes, as well as previous evidence that exhausted-like cells have been associated with immunotherapeutic response in T1D (22). The gene discussed is CD8A; the disease is type 1 diabetes mellitus.