In summary, among the prognostic genes we screened, the potential relationship amongBIRC5, HMOX1, and VEGFA in HCC prognosis had been reported previously, while VPS35might be a newly identified oncogene of HCC, and further, VPS26A and PRKCD were alsofound to have roles related to cancer. The gene discussed is HMOX1; the disease is hepatocellular carcinoma.