TP53 and cancer: In addition, several cancer-related pathways and modules were enriched(P<0.05) including the down-regulation of the cancerinhibitory P53 signaling pathway and the inhibition of apoptosis, as well as theup-regulation of the JAK-STAT signaling pathway, and the pathways in cancer.These results can provide an explanation for the poor survival of patientsobserved in the high-risk group at the molecular level, indicating that the riskmodel we established is reliable.