However, the aberrant activation of NLRP3 inflammasome plays a crucial role in the pathogenesis of several human diseases, such as cryopyrin-associated autoinflammatory syndromes (CAPS), type 2 diabetes (T2D), gout, atherosclerosis, and neurodegenerative diseases (6–13). Here, NLRP3 is linked to cryopyrin-associated periodic syndrome.