PH domain leucine-rich repeat protein phosphatase 2 (PHLPP2) is suppressed by mature miR-25 and miR-25-3p, which leads to the activation of oncogenic AKT-p70S6K signaling, provoking malignant phenotypes of pancreatic cancer cells.[21] Therefore, we tempted to investigate whether miR-25 could become a future biomarker for pancreatic cancer. Here, RPS6KB1 is linked to familial pancreatic carcinoma.