However, a study reported that age was not a risk factor for drug discontinuation due to AEs with TNF inhibitors.[15] Further, it has been reported that TNF inhibitor use does not increase the risk of serious infections in elderly patients with RA compared to non TNF inhibitor users.[16] In this way, there is little evidence to support the association between the age of patients with RA and the rate of AEs onset caused by bDMARDs. This evidence concerns the gene TNF and infection.