MYC and immunodeficiency disease: Burkitt lymphoma is the most aggressive form of non-Hodgkin lymphoma with B lymphocytes,[2] with endemic or sporadic evolution, or being associated with immunodeficiency syndromes: HIV infection, congenital immunodeficiency syndromes or in allografted patients.[3,4] It is characterized by a particularly high rate of proliferation (approximately 100%),[5] with cells doubling time of 24 hours and cytogenetic specific changes of the c-MYC proto-oncogene.