CSF1R and Hereditary diffuse leukoencephalopathy with axonal spheroids and pigmented glia: Secondly, attenuated and aberrant microglial CSF‐1R signalling will induce endothelial tight junction re‐modelling and BBB permeability as we have shown in post‐mortem ALSP cases in addition to contrast‐enhanced MRI studies in a genetically diagnosed ALSP patient.