CSF1R and Hereditary diffuse leukoencephalopathy with axonal spheroids and pigmented glia: We show that dysregulated CSF‐1R‐dependent endothelial/microglial cell crosstalk induces re‐modelling of the BBB in mouse and human and suggests that regulating BBB integrity while promoting macrophage recruitment to the brain may be therapeutically viable in ALSP and other AD‐like dementia.