Accordingly, the current study was designed to investigate the particular function and molecular mechanism underlying the role of BMSC‐EV‐derived let‐7i on lung cancer and our results illustrated that the BMSC‐EV‐derived let‐7i led to the suppression of proliferation, migration and invasion of lung cancer cells by decreasing the FXYD3 by elevating DCLK1 via KDM3A inhibition, thus potentially serving as an effective suppressor of lung cancer development (Figure 8). Here, FXYD3 is linked to lung cancer.