Our results denoted that compared with model mice, the lung tissue damage in mice treated by EV‐let‐7i mimic was reduced with a relatively decreased number of metastatic tumour nodules (p ˂ 0.05), whereas the lung tissue of nude mice transfected with si‐FXYD3 was severely damaged with a relatively increased number of metastatic tumour nodules (p ˂ 0.05). This evidence concerns the gene FXYD3 and neoplasm.