PNPLA3 and metabolic dysfunction-associated steatotic liver disease: These studies found that NAFLD was associated with hypomethylation at FGFR2, MAT1A, CASP120 and PARVB genes21 and hypermethylation at PNPLA3,21PPARα, TGFβ1, Collagen 1A1 and PDGFα genes.22