These studies found that NAFLD was associated with hypomethylation at FGFR2, MAT1A, CASP120 and PARVB genes21 and hypermethylation at PNPLA3,21PPARα, TGFβ1, Collagen 1A1 and PDGFα genes.22 This evidence concerns the gene FGFR2 and metabolic dysfunction-associated steatotic liver disease.