We found that Kdm5a-/- mice indeed showed significant alterations in their emitted USVs indicating abnormal brain development upon loss of Kdm5a. Furthermore, Kdm5a-/- mice showed increased self-grooming and remarkable repetitive forepaw wringing and clasping, a characteristic ASD-like phenotype observed in mouse models of several neurodevelopmental disorders, one of the most well-characterized examples being mouse models of Rett syndrome (Chao et al., 2010). This evidence concerns the gene KDM5A and Rett syndrome.