MAP3K12 and nervous system disorder: Because DLK has been proposed as a target to prevent neuronal cell death or axon degeneration in neurological disease, GNE-3511 was recently developed as a small-molecule inhibitor of DLK that shows selective inhibition of DLK activity and protection against axon pruning with an IC50 of 0.1 μM (Patel et al., 2015).