The relationship between stress granules, MLOs observed in cells after exposure to exogenous stress, and these ALS/FTD‐associated proteins, including FUS, TDP‐43, hnRNPA1, and hnRNPA2, has been a primary focus of work relating MLOs to neurodegeneration (Kim et al, 2013; Burke et al, 2015; Molliex et al, 2015; Patel et al, 2015; Conicella et al, 2016; Monahan et al, 2017; Ryan et al, 2018; Wang et al, 2018a). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.