TARDBP and amyotrophic lateral sclerosis: Conversely, our results also demonstrate that the toxicity caused by mutant hnRNPA2 expression, but not toxicity caused by loss of the C. elegans ortholog of hnRNPA2, is ameliorated by deletion of tdp‐1 (Fig 7), the ortholog of the RNA‐binding protein TDP‐43 that forms aggregates in the majority of ALS cases (Mackenzie & Rademakers, 2008) and co‐aggregates with hnRNPA2 in MSP (Kim et al, 2013).