hnRNPA2 mutations cause multisystem proteinopathy (MSP), a degenerative disease with clinical features of ALS/FTD, inclusion body myopathy, and Paget’s disease of bone (PDB) (mutation: D290V) (Kim et al, 2013) as well as PDB alone in a separate family (mutation: P298L) (Qi et al, 2017). Here, HNRNPA2B1 is linked to neurodegenerative disease.