While regulatory T (Treg) cells have been reported to play a role in regulating obesity-induced adipose tissue inflammation [19], the percentage of circulating FoxP3+CD25high Treg cells within the CD4+ T cell subset was not associated with BMI, HOMA-IR or ISIOGTT in this study (Fig. 1g, Supplementary Table 1). Here, FOXP3 is linked to obesity due to melanocortin 4 receptor deficiency.