Mechanistically, these pro-tumorigenic, fibroblast-stimulating effects of the exosomes released by wild-type p53-deficient colorectal cancer cells are explained by an upregulation of multiple exosomal miRNAs, including miR-1249-5p, miR-6737-5p and miR-6819-5p, which all target the TP53 mRNA [83]. The gene discussed is TP53; the disease is colorectal cancer.