Along with changes in cell migration and invasion, the miR-1246-dependent reprogramming of macrophages induces secretion of, among other factors, IL-10, TGF-β, and matrix metalloproteinases, generating an anti-inflammatory microenvironment, the recruitment of immunosuppressive Tregs, the epithelial-to-mesenchymal transition of tumor cells and increased tumor growth and metastasis. This evidence concerns the gene TGFB1 and neoplasm.