Intriguingly, these exosome-mediated effects also seem to operate over long distances, as mutp53-expressing but not p53-null subcutaneous xenografts as well as p53 mutant autochthonous pancreatic tumors triggered pro-invasive extracellular matrix alterations in the lung that could serve as pre-metastatic niches to facilitate metastatic colonization. The gene discussed is TP53; the disease is pancreatic neoplasm.