PRRX1 and lip and oral cavity carcinoma: Several newly discovered genes have not been previously implicated in UM pathogenesis, including HTN1, MRC2, VWCE, GJB2, LGALS3, and PRRX1. For example, histatin-1, a product of the HTN1 gene, counteracted the effects of EMT inducers on the outgrowth of oral cancer cell spheroids, suggesting that it affects processes that are implicated in cancer progression [25].