GLI2 and neoplasm: Lin28a overexpression was observed to lead to an upregulation of proteins involved in Shh and Wnt signaling (e.g., Axin2, Gli2, N-Myc) while knockdown of Lin28a decreases mRNA levels of genes involved in these pathways (e.g., Gli1, Gli2, Axin2) in a human embryonal tumor with multilayer rosettes (ETMRs) cell line [88].