HOXB1 and osteosarcoma: In murine and human osteosarcoma models it was shown that let-7g targets the 3′ UTR of HOXB1, a suggested inhibitor of NF-κB signaling, and that inhibition of let-7g elevates levels of HOXB1 at the mRNA and protein level which coincides with a decrease in the expression of p50 and p65/RelA at the mRNA and protein level [104].