IGHE and optic nerve disorder: These results indicate that patients with serum IgE above 425 mg/dL are more likely to have extraocular muscle enlargement, while patients with serum IgG4 above 713 mg/dL have a higher probability of lesions involving ocular adnexal tissues and other tissues above the neck, higher frequency of worsened BCVA due to optic neuropathy, and higher frequency of dry eye symptoms.