Patients with worsened BCVA had significantly older onset; higher serum IgG4, WBC count, serum TP, CRP, serum IgG, serum IgA, serum IgE, and β2MG; and higher frequencies of lesion above the neck excluding LG and SG, trigeminal nerve enlargement, extraocular muscle enlargement, orbital mass, orbital diffuse lesion, optic neuropathy, and visual field defect (p = 0.01, p < 0.001, p = 0.003, p = 0.004, p = 0.004, p = 0.02, p = 0.03, p = 0.04, p = 0.002, p = 0.02, p = 0.01, p < 0.001, p = 0.006, p = 0.006, p < 0.001, and p < 0.001, respectively). The gene discussed is CRP; the disease is Optic neuropathy.