These results indicate that patients with serum IgE above 425 mg/dL are more likely to have extraocular muscle enlargement, while patients with serum IgG4 above 713 mg/dL have a higher probability of lesions involving ocular adnexal tissues and other tissues above the neck, higher frequency of worsened BCVA due to optic neuropathy, and higher frequency of dry eye symptoms. The gene discussed is IGHE; the disease is dry eye syndrome.