It is involved in pathologies such as senile systemic amyloidosis (SSA) and familial amyloidotic polyneuropathy (FAP), the latter being an autosomal dominant lethal disease in which amyloid fibrils are mostly constituted by mutant TTR variants [6,7,8], TTR cardiac amyloidosis [9] and other TTR-related cerebral amyloidosis [10]. This evidence concerns the gene TTR and cardiac amyloidosis.