Regarding haplotypes in FokI (rs2228570) with BsmI (rs1544410), ApaI (rs7975232), and TaqI (rs731236) in RA patients, a study that assessed the four VDR SNPs reported that the frequency of carotid plaques was significantly higher in RA patients who carried the GATG (also interpreted as FbAt according to the order of location of the polymorphic sites in VDR). The gene discussed is VDR; the disease is rheumatoid arthritis.