Participants with sever liver fibrosis (FIB-4 > 3.25) had significantly higher plasma levels of IL-1β, IL-4, IL-6, IL-7, IL-9, IL-10, IL-12, IL-13, IL-15, IL-17, IFN-γ, TNF-α, MCP-1, GM-CSF, FGF-basic, and VEGF than those with FIB-4 ≤ 3.25 (all p < 0.05) (Table 2 and Figure 1). The gene discussed is CSF2; the disease is Hepatic fibrosis.