Mice were orthotopically transplanted with syngeneic 7940B PDAC cells derived from a primary spontaneous PDAC tumor arising in the body of the pancreas (C57BL/6) of a male transgenic KrasLSL-G12D/+, Trp53LSL-R172H/+, Pdx1-Cre (KPC) mouse [16]. The gene discussed is PDX1; the disease is neoplasm.