In particular, compared to controls, mice treated with either cabo+PD-1Inh, or chemo+cabo+PD-1Inh triple treatment, significantly decreased tumor weights correlated with a significant decrease in stromal markers alpha smooth muscle actin (Figure 1I), fibronectin and vimentin, and PMN-MDSCs (Figure 1F,H) infiltration, with an increase in CD8+ infiltrating cells (Figure 1E–G). Here, FN1 is linked to neoplasm.