Since PTEN performs GluN2B Y1472 dephosphorylation [37] and perampanel ameliorates NMDAR-mediated neuronal damage induced by ischemia [38], it is postulated that AMPAR antagonism affects NMDAR functions by regulating PTEN-mediated GluN2B Y1472 dephosphorylation, which is elusive. The gene discussed is GRIN2B; the disease is ischemia.