SOX2 and neoplasm: These CSCs, considering the core cell subset of these tumors, express the NSC lineage markers nestin, prominin-1 (CD133), nanog homeobox (NANOG), sex determining region Y-box 2 (SOX2), hematopoietic cell E/L-selectin ligand (HCELL/CD44), octamer-binding transcription factor 4 (OCT4), bear a marked ability to form neurospheres in particular conditions [47,48], and are characterized by a tumor-initiating and self-renewal capacity through asymmetric cell division [3,66,67,68].