miR-221 and -222 have also been reported to be upregulated in A375 melanoma stem-like cells, resulting in reduced levels of their target V-Kit Hardy-Zuckerman 4 feline sarcoma viral oncogene (C-KIT/CD117), a melanocytic functional player with tumor-suppressive activity via apoptosis induction, occurring when its kinase activation is silenced [204]. This evidence concerns the gene KIT and melanoma.