MGLL and obesity due to melanocortin 4 receptor deficiency: These data suggest that the alterations in gut peptide and adipokine levels induced by a HFD are related to HFD-induced changes in the gut microbiome, and that Mgll−/− mouse resistance to HFD-induced and obesity-linked metabolic perturbations may be partly due to gut microbiome-associated alterations in these mediators.