Interestingly, patients with coronary artery disease have an increase in the order Lactobacillales [47], which we found here to be significantly lower in Mgll−/− mice on HFD (p = 0.003 at 22 weeks; data not shown), suggesting that alterations in the gut microbiome of Mgll−/− mice may also contribute to the resistance of these mice to the development of atherosclerosis and supporting the proposition that the gut microbiome-eCBome axis may be relevant to cardiovascular health [20]. This evidence concerns the gene MGLL and coronary artery disorder.