RASSF1 and cancer: After 5–50 mg of resveratrol taken twice a day for 12 weeks, only RASSF-1 methylation was significantly reduced by resveratrol, while PGE2 (a lipid derived prostaglandin identified as a tumorigenic factor in many cancers [139]) was reduced in the nipple aspirate fluid (NAF) of the breast cancer patients that had undergone mammary ductoscopy [140].