A randomized controlled trial conducted for 8 weeks in patients with overweight/obesity and NAFLD showed significant beneficial effects on: (1) body weight, (2) liver transaminases, (3) markers of insulin sensitivity, (4) lipid profile, (5) serum biomarkers of inflammation and, (6) oxidative stress in the DASH diet group compared to low-energy diet [31]. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.