APC and colorectal cancer: According to data from ‘The Cancer Genome Atlas Project’ (TCGA) available at the National Cancer Institute Genomic Data Commons (https://portal.gdc.cancer.gov, [131]) and the cBioportal for cancer (https://www.cbioportal.org, [132,133]), in >80% of human colorectal cancers, initiator mutations occur in the Apc gene (Figure 2).