G6PC1 and Hypoglycemia: The inclusion of further 5′usptream nucleotides of the human G6PC promoter sequence (−2864 to −1) to the AAV8-G6pc vector completely normalized G6Pase activity in 2–4 weeks-old G6pc-/- mice, restored normal blood glucose levels and normal glycogen and lipid storage in the liver, and prevented the development of fasting hypoglycemia [124].