While we showed indications of cytoskeletal and/or ECM remodeling (through changes to the dystrophin-associated protein complex (DAPC) and the MMP-9 to MMP-2 ratio) driven by both IRI and the addition of BGP-15, it is difficult to conclude whether these changes are short-lived and ultimately beneficial or whether they detrimentally progress a muscular dystrophy-like phenotype. The gene discussed is MMP9; the disease is muscular dystrophy.