TNF and rheumatoid arthritis: Besides the well-known antioxidant properties of medium-chain fatty acids and vitamin E, their anti-inflammatory effects develop in reducing the expression of pro-inflammatory cytokines involved in the progression of RA, such as Interleukin (IL)-1Beta, IL-17, and Tumor Necrosing Factor (TNF)-alpha [8]; in addition, it is posited that the down-regulation of the expression of vascular cell adhesion molecules and intracellular adhesion molecules on immune system cells and vascular endothelial cells modulates the inflammatory response in RA [6].