Both carriers and non-carriers of the primordial MS-associated HLA risk alleles, i.e., HLA-DRB1*15:01, HLA-DQA1*01:02 and HLA-DQB1*06:02—either alone or combined in the HLA-DR15 haplotype—demonstrated myelin responsiveness to at least one of the tested peptides in the same extent (Table 4). The gene discussed is HLA-DQB1; the disease is myeloid sarcoma.