Flow cytometry revealed that >95% of KC and AC cells were positive for SCA-1 (97% and 98%, respectively) (Figure 4C), with SCA-1+ cells being implicated as CSCs that possess a high tumor-propagating ability and which give rise to intra-tumoral heterogeneity through generation of a differentiation hierarchy [38,39,40,41]. Here, CALCA is linked to neoplasm.