NGS coupled with mutation enrichment PCR have proven to identify the EGFR T790M mutation in liquid biopsies of NSCLC patients with high sensitivity (93% for plasma and urine samples of the recommended volume of 90–100 mL) and specificity (94% and 96% for plasma and urine, respectively) [69]. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.