One of the promising strategies for combating carcinogenesis is to search for substances that can prevent the transformation of normal cells into cancer cells induced by various stimulating factors, e.g., epidermal growth factor (EGF), triphorbol ether (TPA), ultraviolet radiation (UV), etc. The promotion-sensitive mouse epidermal JB6 Cl41 cells are known to respond irreversibly to tumor promoters such as epidermal growth factor (EGF) with induction of anchorage-independent growth in soft agar [37]. The gene discussed is EGF; the disease is cancer.