DCLK1 and pancreatic neoplasm: A recent study demonstrated that overexpression of DCLK1-AL in pancreatic tumor cells can lead to polarization of M1-macrophages towards an M2-phenotype characterized by secretion of chemokines and cytokines such as IL-6, IL-10, and CXCL12, which enhance tumor cell migration, invasion, and self-renewal [28].