CD274 and neoplasm: The tumor immune microenvironment (TIME) refers to the microenvironment as it relates to immune cells including: infiltrated-excluded TIME in which there is a relative lack of cytotoxic T lymphocytes in the core location of the tumor; infiltrated–inflamed TIME in which infiltration occurs to a large degree with expression of immune negative regulatory receptor PD-1 of CTLs and inhibitory PD-L1 of leukocytes; and tertiary lymphoid structure TIME, which contains a large number of lymphocytes, including initial and activated T-cells, regulatory T-cells, B cells, and dendritic cells [74].