After twenty years of research, DCLK1 is accepted as a specific marker of TCs and several kinds of CSCs, and is well known for its ability to regulate tumor growth, invasion, metastasis, epithelial-mesenchymal transition (EMT), pluripotency, angiogenesis, and pro-survival signaling [18,19,20,21]. Here, DCLK1 is linked to neoplasm.