Kato et al. showed that loss of the G9a (EHMT2) histone methyl transferase results in a decrease in the number of Dclk1-positive cells and correlated reduction in Erk phosphorylation in mouse pancreatic intraepithelial neoplasia (mPanIN) lesions of a pancreatic cancer mouse model [70], which concurs with findings in the Dclk1Cre;KrasLSL-G12D model of pancreatic tumorigenesis [69]. Here, EHMT2 is linked to familial pancreatic carcinoma.