At least three putative autoantigens implicated in Psoriasis have been identified so far: cathelicin LL37 [93], disintegrin-like and metalloprotease domain containing thrombospondin type 1 motif-like 5 (ADAMTSL5) [99] and keratin 17, whose involvement is mainly based on the homology to streptococcal M-proteins [94], since streptococcal infection is considered a major environmental trigger of the disease. The gene discussed is ADAMTSL5; the disease is psoriasis.