Pregnant women with HAE with low level or functional deficiency of C1-INH should be treated with plasma-derived C1 inhibitor concentrate until 6 hours before delivery and could be repeated as needed, as well as 72 hours after the delivery.1The hospital where the delivery will take place should have short-term preventive medications such as plasma-derived C1 inhibitor concentrate and trained personnel for the care of patients with HAE.4, 5, 6. This evidence concerns the gene SERPING1 and hereditary angioedema.