In congenital forms, fresh frozen plasma is enough to augment ADAMTS13 levels.3, 15Once platelet count is restored, the frequency of plasmapheresis or plasma infusion will depend on subsequent platelet count and ADAMTS13 activity levels.17Platelet transfusions may precipitate central nervous system (CNS) symptoms, so they are contraindicated.3, 15Pregnancy may trigger both acquired and congenital TTP. Here, ADAMTS13 is linked to thrombotic thrombocytopenic purpura.