In our study we confirmed that loss of T cells in both Lck−/− SD rats and Cd3e−/− SD rats, liver fibrosis was significantly diminished accompanied by dramatic reduction CD11b+ myeloid cells and B lymphocytes in the infected liver, suggesting that even in the resistant SD rats T cells are involved in both resistance to infection and also play important role in development of liver fibrosis. The gene discussed is LCK; the disease is infection.