NR1H4 and obesity due to melanocortin 4 receptor deficiency: We identified glycine-β-muricholic acid (Gly-MCA) as a selective high-affinity inhibitor of intestinal FXR signaling that can reverse HFD-induced obesity by reducing the biosynthesis of intestinal-derived ceramides, which directly compromises beige fat thermogenic function (Jiang et al., 2015).