Kaplan–Meier unclosed that elevated CDK5R1 had a significant correlation with worse overall survival (OS; P=7.414e−04), disease-specific survival (DSS; P=5.642e−04), disease-free interval (DFI; P=1.785e−05) and progression-free interval (PFI; P=2.512e−06), which suggested that HCC patients with high CDK5R1 had a tendency to have shorter survival time than that with low CDK5R1 (Figure 3A–D). This evidence concerns the gene CDK5R1 and hepatocellular carcinoma.