CDK5R1 and neoplasm: However, at multivariate Cox regression analysis, CDK5R1 expression (high vs. low; P=0.037, HR = 1.7 (95% CI [1.0–2.7])), tumor status (with tumor vs. tumor free; P=0.004, HR = 3.3 (95% CI [1.5-7.6])), the expression of CDC25B (high vs. low; P=0.011, HR = 1.9 (95% CI [1.2-3.1])) could independently predict adverse OS (Table 3, Figure 4A).