AFP and neoplasm: As shown in (Figure 2A–F), increased CDK5R1 had a significant correlation with histologic grade ((G1-2 vs. G3-4, P=0.004), clinical stage (Stage I−II vs. Stage III−IV, P=2.185e−04), topography (T1-2 vs. T3-4, P=5.232e−04), tumor status (P=0.002), AFP (AFP<20 vs. 20≤AFP<400 vs. AFP≥400, P=0.023) and new tumor event (P=0.016).