Up to date, there have been no reports on the role of CDK5R1 in HCC, but to our knowledge, CDK5R1 encodes the activator p35 of CDK5, which must be combined with the activator to work and thus CDK5R1 plays a pivotal role in regulating the appropriate activity of CDK5 [8]. This evidence concerns the gene CDK5 and hepatocellular carcinoma.