MAPT and Alzheimer disease: Despite the uncertainty about the relative roles of Aβ andtau in AD, the stronger correlation between NFTs and memory impairmentsuggests the existence of a closer connection between tau pathologyand neurodegenerative events than those observed with Aβ aggregates.49 Moreover, since tau mutations responsible forsome frontotemporal dementia were identified,50 it was also possible to generate transgenic models showing severetau pathology.51 This aspect is of crucialimportance for the demonstration of in vivo pharmacodynamiceffects of tau-based drugs.