Most of these ligands were based on the structure of AChEinhibitor tacrine.139 In 2018, Sun andco-workers speculated that compounds able to simultaneously inhibitGSK-3β and AChE may represent suitable anti-AD agents due totheir ability to interfere with NFTs and Aβ plaques formations.140 Hence, they reported the first class of dualGSK-3β/AChE inhibitors starting from the structure of tacrine,as AChE inhibitor, and a pyridothiazole as GSK-3β inhibitor 4 (Figure 5). This evidence concerns the gene ACHE and Alzheimer disease.