WEE1 and Alzheimer disease: For this reason, kinases have been intensively investigatedas drug targets and 52 kinase inhibitors have been approved by theFDA.104 These drugs target nearly 20 differentkinases, but most of them are used for the treatment of proliferativediseases.104 Recent evidence highlightsthat CNS protein kinases are emerging as important therapeutic targetsin AD.65 GSK-3β is probably the mostknown kinase involved in AD.