Even if tau and tangles are not specificfor AD, the correlationbetween cognitive dysfunctions and the localization of tangles presentin this neurodegenerative disorder is very strong.42 Intraneuronal tangles containing hyperphosphorylated tauare a well-known hallmark of AD pathology, along with senile plaquescontaining extracellular amyloid-β (Aβ).43 Aβ is physiologically produced even if its role innormal brain is not completely understood. Here, MAPT is linked to Alzheimer disease.