GSK3B and neoplasm: Indeed, many components of the Wnt/β-cateninpathway are involved in several cancers and GSK-3β inhibitorsmay be potentially oncogenic since GSK-3β suppresses tumor development.126 Indeed, this pathway affects several proto-oncoproteins,cell cycle regulators, and mediators of the epithelial to mesenchymaltransition, which is critical for cancer metastasis.