Among these proteins, PKB/Akt is able to inactivatethe kinase through phosphorylation in response to insulin.76 What turns GSK-3β into an appealing targetfor neurodegenerative disease is its deep implication in the Wnt-β-cateninsignaling pathway, profoundly implicated in embryonic developmentand human homeostasis.77 The gene discussed is AKT1; the disease is neurodegenerative disease.