In normal condition, tau is highlyhydrophilic, while abnormal hyperphosphorylation is the most compellingcause of tau dysfunction.29 Hyperphosphorylatedtau and aggregates are not able to bind to tubulin and promote microtubuleassembly causing their disruption.30,31 However, otheralterations such as conformational changes32 and truncation of tau33 have also beenimplicated in AD pathogenesis. The gene discussed is MAPT; the disease is Alzheimer disease.