For instance,(a) BACE-1 promotes Aβ formation, which in turn leads to anoveractivation of GSK-3β, which consequently induces an increasein the formation of NFTs, inflammation, and cognitive impairment,132 and (b) GSK-3β regulates the activitiesof secretases.92 By exploiting a ligand-basedapproach, the authors identified and combined the pharmacophoric featuresresponsible for GSK-3β and BACE-1 inhibition. This evidence concerns the gene BACE1 and Cognitive impairment.