MAPT and Alzheimer disease: Although NFTs are considered one of the two hallmarksof the disease, recent evidence suggests that other forms of tau maybe more toxic than NFTs, such as small soluble tau oligomers.35−38 This was also observed for other AD-related proteins like Aβand α-synuclein,39 where solublespecies were in fact the most toxic.40,41 In addition,some reports even discuss a possible protective role for NFTs.35 Of course, more studies are still necessaryto confirm these findings.