It is known that tumor cells secrete a widely spectrum of substance, including interleukin-1 (IL-1), interleukin-6 (IL-6), granulocyte-macrophage colony-stimulating factor (GM-CSF), granulocyte colony-stimulating factor (G-CSF), able to mediate the interaction with platelet activation. The gene discussed is CSF2; the disease is neoplasm.