Hypoalbuminemia could exert directly and indirect effect on bone turnover which leads to shift the balance towards to resorption processes by acting on the nuclear factor-kappa B, inflammatory processes and antioxidant activities that reduced bone mineral density, resulting in a decrease of calcium phosphate (hydroxyapatite) crystals formation, and also affects concentration of parathyroid hormone (PTH) and vitamin D3 (2). The gene discussed is PTH; the disease is Hypoalbuminemia.