Promoter methylation of DKK4 and DKK2 genes was identified in healthy controls whereas methylation status of those genes in OSCC samples was detected as semimehtylation of only DKK2. It was semimethylated in 5 OSCC patients with well and moderately differentiated tumor grades while it was unmethylated in 77.4% of the healthy controls. The gene discussed is DKK2; the disease is neoplasm.