NFKB1 and melanoma: In this study, the effects of small-interfering (si)-HOTAIR transfection on the proliferation and apoptosis of malignant melanoma cells were detected via cell counting kit-8 (CCK-8) assay, 4’,6-diamidino-2-phenylindole (DAPI) staining and flow cytometry, respectively, the changes in NF-κB pathway-related proteins and apoptosis-associated proteins after interference in lncRNA HOTAIR were detected via quantitative reverse transcription-polymerase chain reaction (qRTPCR) and Western blotting, and the regulatory mechanism of the NF-κB pathway was further explored.