Meanwhile, HSCs were cultured in cancer-CM with simultaneous TU-100 treatment (90: 90 μg/mL, 270: 270 μg/mL, and 900: 900 μg/mL), which were called as modified HSCs, and α-SMA and IL-6 mRNA expressions were significantly reduced in modified HSCs with TU-100 treatment (270, 900) (p < 0.05, Figure 1B). Here, ACTA1 is linked to cancer.