Indeed, ChIP-qPCR for LXRα identified increased binding of LXRα at promoters of Srebf1 and Scd1 (Figure 7G; p=0.0093 for Srebf1 promoter and p=0.0213 for Scd1 promoter), both of which are lipogenic genes and are direct targets of LXR (Repa, 2000; Chu et al., 2006), suggesting that LXR might be directly responsible for the increase in SREBP1c levels (Figure 6D–E) and therefore lead indirectly to hepatic steatosis. Here, SREBF1 is linked to fatty liver disease.