NR1H3 and Hepatic steatosis: Indeed, ChIP-qPCR for LXRα identified increased binding of LXRα at promoters of Srebf1 and Scd1 (Figure 7G; p=0.0093 for Srebf1 promoter and p=0.0213 for Scd1 promoter), both of which are lipogenic genes and are direct targets of LXR (Repa, 2000; Chu et al., 2006), suggesting that LXR might be directly responsible for the increase in SREBP1c levels (Figure 6D–E) and therefore lead indirectly to hepatic steatosis.